Bone morphogenetic protein-2-derived osteogenic peptide promotes bone regeneration via osteoblastogenesis.

ABSTRACT:

Introduction

Bone morphogenetic protein (BMP)-2 plays a critical role in stimulating human mesenchymal stromal cells (hMSCs) differentiation, a key process in bone regeneration. However, the clinical application of BMP-2 has been hindered by several adverse effects. This study evaluated the effectiveness of a newly synthesized BMP2-derived osteogenic peptide (OP), which may overcome the limitations of BMP-2 while preserving its osteogenic potential.

Methods

OP5, selected from the OP family based on its osteogenic potential, was tested in vitro to compare its effects on osteogenic signaling, osteoblast differentiation, and hMSC gene expression in with those of BMP-2. New bone formation stimulated by OP5 or BMP-2 was assessed in vivo using radiographic and histol

SUBMITTER: Lee JB 

PROVIDER: S-EPMC12553006 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature