Integrating multi-modal omics to identify therapeutic atherosclerosis pathways for coronary heart disease.

ABSTRACT:

Background

Urinary metabolism breakdown products reflect metabolic changes in atherosclerosis-relevant tissues and may contain relevant therapeutic leads. We integrated data on urinary metabolism breakdown products, plasma proteins, atherosclerotic plaque tissue, and single-cell expression to identify druggable metabolic pathways for coronary heart disease (CHD).

Methods

Mendelian randomisation was employed to interrogate findings from independent genome-wide association studies on 954 urinary metabolism breakdown products, 1562 unique proteins, and 181,522 CHD cases, establishing directionally concordant associations. Using the Athero-Express Biobank, concordant plasma proteins were linked to plaque vulnerability using protein and mRNA expression in plaque. Single-cell RNA

SUBMITTER: de Ruiter SC 

PROVIDER: S-EPMC12553007 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature