Alzheimer's disease and its progression reduce pyramidal cell gain and connectivity.

ABSTRACT:

Introduction

Alzheimer's disease (AD) affects neurophysiology by loss of neurons, synapses, and neurotransmitters. A mechanistic understanding of the human disease will facilitate new treatments.

Methods

Magnetoencephalography was recorded during an auditory mismatch negativity paradigm from healthy adults (n = 14) and people with symptomatic AD (n = 45, amyloid biomarker positive) at baseline and after 16 months. Fourteen people with AD had repeat magnetoencephalography at 2 weeks to assess test-retest reliability. Dynamic causal models were fitted to the evoked responses and analyzed using parametric empirical Bayes.

Results

Sensor data confirmed that AD and its progression reduce the mismatch negativity amplitude, which had excellent test-retest reliability. Parame

SUBMITTER: Lanskey JH 

PROVIDER: S-EPMC12553034 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature