Genetic association between microRNA gene polymorphisms and polycystic ovary syndrome susceptibility: A systematic review and meta-analysis.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, associated with genetic and environmental factors, including microRNA (miRNA) gene polymorphisms.

Objective

To evaluate the association between miRNA gene polymorphisms and PCOS.

Search strategy

PubMed, Embase, Web of Science, and Scopus databases were searched to September 2024, using MeSH terms including "MicroRNAs", "Polymorphism, Single Nucleotide," and "Polycystic Ovary Syndrome".

Selection criteria

Case-control studies investigating the relationship between miRNA gene polymorphism and PCOS were included.

Data collection and analysis

Two researchers collected the data independently. The risk of bias was assessed using the Newcastle-Ottawa Scal

SUBMITTER: de Souza ATB 

PROVIDER: S-EPMC12553106 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature