Simulated daylight vs. conventional PDT for clinical superficial BCC: A randomized controlled trial.

ABSTRACT:

Background

Photodynamic therapy (PDT) is a recognized treatment for superficial basal cell carcinoma (sBCC). Conventional PDT (C-PDT) has a relatively high clearance rate but is time-consuming and painful. Simulated daylight PDT (SDL-PDT) has the potential advantage of causing less pain, but its effectiveness has not been investigated thoroughly.

Objectives

To determine whether SDL-PDT is non-inferior to C-PDT in the treatment of clinically diagnosed sBCC and to assess adverse events during treatment and patient preferences.

Methods

In this single-centre, non-inferiority, randomized controlled trial, adult patients with sBCCs of any size and located on anatomical sites suitable for PDT were recruited. Lesions were randomized to two sessions of either SDL-PDT or C-PDT

SUBMITTER: Sjoholm A 

PROVIDER: S-EPMC12553125 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature