Remote spatial memory deficits in mouse models of neuropsychiatric disorders with immature dentate gyrus phenotype.

ABSTRACT:

Background

The hippocampal dentate gyrus (DG) is a critical region that contributes to recent and remote memory. Granule cells within this region, in which adult neurogenesis occurs, undergo dynamic and reversible maturation via genetic and environmental factors during adulthood. A pseudo-immature state of DG granule cells, called immature DG (iDG), has been observed in the adult mice of certain mutant strains, which are considered animal models of neuropsychiatric and neurodegenerative disorders, such as intellectual disability, schizophrenia, autism, and Alzheimer's disease. However, the association between the iDG phenotype and recent and remote memories in the mouse models remains unclear.

Methods

We assessed spatial memory in the Barnes circular maze task in five mutant

SUBMITTER: Shoji H 

PROVIDER: S-EPMC12553137 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature