RBM15 is a novel prognostic biomarker and correlates with immune cell infiltration in lung adenocarcinoma.

ABSTRACT:

Background and aims

This study aimed to evaluate RBM15 gene expression and the potential effects as a biomarker in LUAD progression.

Materials and methods

The RNA sequencing (RNA-seq) data and clinical data of patients with LUAD were acquired from The Cancer Genome Atlas (TCGA) databases. Kaplan-Meier (K-M) curves were generated to investigate the relationship between RBM15 and the prognosis of patients with LUAD. Gene Ontology (GO) and Reactome enrichment analyses were performed using the "cluster Profiler" R package. Finally, the Tumor Immune Estimation Resource (TIMER)database and CIBERSORT algorithm were used to assess the correlations between RBM15 expression and immune infiltration in LUAD.

Results

RBM15 was upregulated in tumor tissue, and it was regarded as an

SUBMITTER: Ma M 

PROVIDER: S-EPMC12553164 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature