Therapeutic effects of cinnamic acid in a rat model of collagenase-induced Achilles tendinopathy.

ABSTRACT:

Background

Achilles tendinopathy is a common degenerative disorder characterized by pain, impaired function, and poor tissue regeneration. Effective treatment remains a challenge due to the tendon's limited healing capacity. Cinnamic acid, a naturally occurring phenolic compound, has demonstrated anti-inflammatory and antioxidant effects in various tissue repair models. However, its therapeutic potential in tendon injury remains unexplored, and this study represents the first study to evaluate its effects in an experimental Achilles tendinopathy model.

Methods

In this experimental study, tendinopathy was induced in male rats via ultrasound-guided collagenase injection into the right Achilles tendon. Animals were randomly assigned to six groups (n = 7 each): Sham, Injury Cont

SUBMITTER: Capkin S 

PROVIDER: S-EPMC12553171 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature