Therapeutic hypothermia in patients with traumatic brain injury: an umbrella review.

ABSTRACT:

Background

Therapeutic hypothermia (TH) is an intervention conducted to reduce brain damage in neonatal asphyxia and postcardiac arrest patients. Traumatic brain injury (TBI) dysregulates cerebral blood flow and causes ischemic brain damage. TH could lower brain damage by reducing the metabolism rate and need for oxygen. In this umbrella review, we aim to investigate different aspects of TH intervention in TBI patients.

Methods

We searched MEDLINE, Scopus, Embase, Cinahl, Epistemonikos, Cochrane Library, Web of Science, and Google Scholar for relevant systematic reviews until August 03, 2025. Then, studies entered the screening process, and systematic reviews of TH`s effect on TBI patients were included. We excluded studies without any quality assessments. Data for mortality

SUBMITTER: Ashayeri H 

PROVIDER: S-EPMC12553179 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature