The combined effect of statin and vitamin C in patients with pulmonary septic shock: a single-center, double-blind clinical trial.

ABSTRACT:

Background and purpose

Treating septic shock requires a multifactorial plan, such as anti-inflammatory drugs and newer drugs to reduce inflammation. This study investigated the effect of a combination (statin and vitamin C) on septic shock mortality and disease symptoms.

Methods

In this double-blind clinical trial study, 60 patients with septic shock hospitalized in the intensive care unit were assigned into two groups: intervention (1 gram of vitamin C was prescribed once a day for 5 days, and atorvastatin 40 mg daily) and control (routine treatment). Inflammatory parameters (C-reactive protein (CRP), lactate dehydrogenase (LDH), and serum ferritin (SF) and lactate), patient conditions, and Sequential Organ Failure Assessment (SOFA) scores were monitored and recorded on the

SUBMITTER: Farzanegan B 

PROVIDER: S-EPMC12553233 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature