Genomic landscape of endometrial polyps.

ABSTRACT:

Background

Endometrial polyps are common, localized overgrowths of endometrial glands and stroma that protrude into the uterine cavity. These tumor-like lesions can cause symptoms like abnormal uterine bleeding and infertility, and they may undergo malignant transformation. The etiology of endometrial polyps remains largely unknown.

Methods

Here, we conducted whole-genome sequencing and global gene expression profiling on 23 polyps. Major findings were validated with targeted DNA (Sanger sequencing) and protein (immunohistochemistry) level analyses. Sanger sequencing was also utilized to validate the observed novel alterations in an additional set of 54 polyp samples.

Results

The most common alterations were chromosomal rearrangements affecting HMGA1 and HMGA2, identi

SUBMITTER: Reinikka S 

PROVIDER: S-EPMC12553238 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature