Tuberculosis vaccination: microbiological and immunological summary of a series of experimental challenge studies.

ABSTRACT: The complexity of bovine tuberculosis (TB) epidemiology, especially in extensive livestock systems with wildlife reservoirs, calls for novel control strategies such as vaccination. This study evaluated the comparative efficacy of homologous and heterologous inactivated vaccines against that of the live Bacille Calmette-Guérin (BCG) vaccine on M. bovis isolation, gross TB lesions, and immune responses. Data from four controlled vaccination and challenge trials involving 41 calves were analysed. Animals were vaccinated with live BCG or heat-inactivated M. bovis via oral or parenteral routes, and immunologic and post-mortem analyses were conducted to evaluate vaccine performance. Compared with nonvaccinated controls, all vaccination strategies significantly reduced M. bovis bacterial loads in

SUBMITTER: Juste RA 

PROVIDER: S-EPMC12553269 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature