Dynamic functional connectivity and coupling analysis of triple networks and white matter functional networks in first-episode schizophrenia patients: mechanisms revealed by follow-up studies.

ABSTRACT:

Background

Patients with schizophrenia exhibit widespread disruptions in large-scale brain network communication, particularly within the default mode network (DMN), central executive network (CEN), and salience network (SN) - collectively termed the triple networks. While existing research has established the association between functional abnormalities in these networks and the pathophysiological mechanisms of schizophrenia, investigations into white matter's functional role remain limited. Specifically, the involvement of white matter in dynamic interactions among the triple networks remains unclear. Dynamic functional connectivity (DFC), capable of capturing time-varying characteristics of brain activity, may offer novel insights into both triple network dysfunction and white m

SUBMITTER: Wu X 

PROVIDER: S-EPMC12553273 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature