Mitochondria-associated endoplasmic reticulum membrane (MAM)-associated calpains system in preeclampsia.

ABSTRACT:

Background

Preeclampsia (PE) is a multisystem disorder characterized primarily by hypertension and proteinuria after 20 weeks of gestation, significantly impacting maternal and fetal health. The etiology remains unclear, but it is primarily attributed to placental dysfunction leading to systemic vascular endothelial damage and inflammatory responses. Mitochondria-associated endoplasmic reticulum membranes (MAMs) influence mitochondrial and endoplasmic reticulum (ER) function by regulating calcium homeostasis, autophagy, and apoptosis. In PE, mitochondrial dysfunction and ER stress have been widely observed. However, detailed investigations into the specific mechanisms and roles of MAMs in PE remain limited. Thus, this study aimed to investigate how MAM-associated biomarkers affect

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12553276 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature