Doblin: inferring dominant clonal lineages from high-resolution DNA barcoding time series.

ABSTRACT:

Motivation

The lineage dynamics and history of cells in a population reflect the interplay of evolutionary forces they experience, including mutation, drift, and selection. When the population is polyclonal, lineage dynamics also manifest the extent of clonal competition among co-existing mutational variants. If the population exists in a community of other species, the lineage dynamics could also reflect the population's ecological interaction with the rest of the community. Recent advances in high-resolution lineage tracking via DNA barcoding, coupled with next-generation sequencing of bacteria, yeast, and mammalian cells, allow for precise quantification of clonal dynamics in these organisms.

Results

In this work, we introduce Doblin, an R suite for identifying dominant b

SUBMITTER: Gencel M 

PROVIDER: S-EPMC12553330 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature