Association Between Statins Use and Major Bleeding in Patients Using Direct Oral Anticoagulants for Atrial Fibrillation.

ABSTRACT:

Background

Direct oral anticoagulants (DOAC) were developed as an alternative to vitamin K antagonists in the treatment of NVAF. Statins are frequently prescribed drugs for the prevention of atherosclerotic cardiovascular disease. A potential interaction between DOACs and statins has been described, suggesting that their concomitant use may increase the risk of major bleeding (MB).

Purpose

To estimate the risk of MB associated with concomitant use of DOACs and statins to assess potential safety issues.

Methods

A case-control study nested in a cohort of new users of DOACs was performed in BIFAP. Cases were defined as MB events and matched to four controls by risk-set sampling. Treatment episodes were built to define the participants' exposure according to their use at

SUBMITTER: de Burgos-Gonzalez A 

PROVIDER: S-EPMC12553355 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature