Phenotypes of Hypertension: Impact of Age and Sex on Hemodynamic Mechanisms.

ABSTRACT:

Background

Essential hypertension is often treated as a uniform condition. However, it encompasses distinct patterns of blood pressure elevation such as isolated systolic, systolic diastolic, and isolated diastolic hypertension, which vary in prevalence according to age and sex. We hypothesized that different hemodynamic mechanisms account for the age- and sex-related differences in these hypertensive phenotypes.

Methods

In this cross-sectional analysis of the ACCT (Anglo-Cardiff Collaborative Trial), 5371 individuals (2402 male), aged 18 to 92 years, free of cardiovascular disease and medication were included. Blood pressure, cardiac output, stroke volume, peripheral vascular resistance (PVR), and aortic pulse wave velocity were measured. Within each sex, subjects were stra

SUBMITTER: Cseh D 

PROVIDER: S-EPMC12553408 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature