Association of Albuminuria With 1-Year Risk of Heart Failure and Other Adverse Outcomes in Atrial Fibrillation.

ABSTRACT:

Background

Albuminuria is associated with increased stroke risk in atrial fibrillation (AF), but its relationship with heart failure (HF) and other adverse outcomes in AF is less well understood.

Methods

Using linked administrative databases, we conducted a retrospective cohort study of individuals aged ≥66 years who were newly diagnosed with AF between April 2009 and March 2019 in Ontario, Canada. Albuminuria was assessed using (1) urine albumin-to-creatinine ratio (UACR, mg/g) and (2) dipstick proteinuria (negative, trace, 1+, 2+, ≥3+). Cause-specific hazards regression estimated adjusted hazard ratios (HRs) for HF hospitalizations or emergency department visits, stroke hospitalizations, bleeding hospitalizations, and death over 1 year.

Results

We included 64 717 in

SUBMITTER: Odutayo A 

PROVIDER: S-EPMC12553413 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature