Activation of Chemokine (C-C Motif) Receptor 1 Modulates α_1B-Adrenoceptor and Arginine Vasopressin Receptor 1A Signaling and Function.

ABSTRACT:

Background

We reported previously that α_1B-AR (α_1B-adrenoceptor) and AVPR1A (arginine vasopressin receptor 1A) heteromerize with CCR1 (C-C motif [chemokine] receptor 1) in human monocytes, through which CCR1 is controlled. Whether CCR1 affects α_1B-AR and AVPR1A signaling and whether such complexes are detectable in human vascular smooth muscle cells (hVSMCs) is unknown.

Methods and results

Bioluminescence resonance energy transfer suggested that the receptors can form hetero-oligomeric complexes. Activation of CCR1 with CCL23 (chemokine [C-C motif] ligand 23) increased the efficacy of aVP (arginine vasopressin)-stimulated AVPR1A and reduced the efficacy of phenylephrine-stimulated α_1b-AR to activate guanine nucleotide-binding prote

SUBMITTER: Gao X 

PROVIDER: S-EPMC12553424 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature