Efficacy and Safety of Heart Failure Treatment According to Frailty Status: A Systematic Review.

ABSTRACT:

Background

Guideline-directed treatment is often withheld in frail patients with heart failure (HF) due to concerns about intolerability, yet they may benefit given the higher risk of HF complications. This systematic review evaluates the efficacy and safety of HF therapy according to frailty levels.

Methods

We searched Medline, Embase, and Web of Science for randomized clinical trials on HF therapies reporting outcomes by frailty status (as defined by the study). Data were summarized in a harvest plot, and a meta-analysis was conducted where possible.

Results

We identified 12 studies: 6 on medication; 3 on exercise/rehabilitation; and 1 each on disease management programs, telemonitoring, and implantable cardioverter-defibrillators. Most studies found no significant

SUBMITTER: Nijskens CM 

PROVIDER: S-EPMC12553454 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature