Circulating Mucosal-Associated Invariant T Cells Are Associated With Acute Human Ischemic Stroke and Predict Poor Outcome.

ABSTRACT:

Background

Mucosal-associated invariant T (MAIT) cells are involved in acute ischemic stroke in mice models. This study aimed to clarify the dynamics and role of circulating MAIT cells in patients with acute ischemic stroke.

Methods

Patients with acute ischemic stroke were classified according to the National Institutes of Health Stroke Scale into severe (score ≥ 10) and mild (score < 10) groups; outpatients with matched sex and age were selected as controls. Circulating MAIT cells, activation (CD69+), and cytokine production (IFN-γ [interferon-gamma] + and IL-17 [interleukin-17]+) on days 3, 10, and 17 after stroke, along with invariant natural killer T cells, gamma delta T cells, CD4+, and CD8+ T-cell populations, were analyzed by flow cytometry. The relationship between M

SUBMITTER: Ozawa T 

PROVIDER: S-EPMC12553461 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature