Adenosine A_2A Receptor in the Choroid Plexus Modulates Ischemia-Reperfusion Injury in the Cortex.

ABSTRACT:

Background

Stroke remains a leading cause of death and disability worldwide, but the therapeutic efficacies of the mainstay treatments, mechanical thrombectomy and intravenous thrombolysis, are limited due to constraints such as the narrow treatment window and the issue of reperfusion injury following restoration of blood flow. Ischemia-reperfusion (I/R) injury is characterized by the infiltration of peripheral leukocytes, which are believed to enter the central nervous system through the breakdown of the blood-brain barrier. However, the involvement of the choroid plexus (ChP), a part of the blood-cerebrospinal fluid barrier, in development of I/R injury is often overlooked. The adenosine A_2A receptor (A_2AR) is recognized as an important regulator of ischemic

SUBMITTER: Lin X 

PROVIDER: S-EPMC12553465 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature