Adherence to Lipid-Lowering Therapies and Cardiovascular Outcomes in Patients With Atherosclerotic Cardiovascular Disease: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Persistently elevated low-density lipoprotein cholesterol is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Despite the availability of lipid-lowering therapy (LLT), most patients with ASCVD do not achieve guideline-recommended low-density lipoprotein cholesterol goals. Poor adherence to LLT is a key barrier to low-density lipoprotein cholesterol lowering and may be associated with adverse cardiovascular outcomes. We conducted a systematic review and meta-analysis to clarify the relationship between adherence to LLT and cardiovascular outcomes in patients with ASCVD.

Methods

Systematic searches of PubMed, Embase, Scopus, and Cumulative Index to Nursing and Allied Health Literature were performed in March 2023 (updated September 2024). Obse

SUBMITTER: Jones LK 

PROVIDER: S-EPMC12553466 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature