Spatial Proteomic Analysis Highlights Molecular Reprogramming in Optic Nerve Invasive Retinoblastoma.

ABSTRACT:

Purpose

Molecular reprogramming at the interface between malignant and non-malignant contributes to heterogeneity and metastasis across various cancers. The optic nerve metastasis serves as a significant prognostic indicator for mortality in retinoblastoma (RB). This study seeks to unveil the molecular underpinnings of this phenomenon.

Methods

We conducted a spatial proteomic analysis to delineate the heterogeneity within three RB samples exhibiting optic nerve invasion (ONI): case 1 and case 2 comparing the optic nerve invasive (ONI) group and the intraretinal group, and case 3 comparing tumor boundary and center. Data were archived in Mendeley Data [V1] (doi: 10.17632/xvtw7gmhzx.1; doi: 10.17632/mbsh6pcsnc.1). Immunofluorescence was performed to validate the expression pat

SUBMITTER: Zhu T 

PROVIDER: S-EPMC12553476 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature