Novel endoluminal parameters for predicting primary loss of response in Crohn's disease: a multi-center study.

ABSTRACT:

Objectives

Approximately 30% of patients with Crohn's disease (CD) experience primary loss of response (PLR) to ustekinumab. However, studies integrating imaging parameters to predict PLR remain limited. This study aimed to quantify endoluminal and intestinal wall parameters using computed tomography enterography (CTE) and assess their predictive value for PLR to ustekinumab.

Materials and methods

This multicenter study analyzed 466 intestinal segments from 161 patients with CD between March 2020 and May 2024. A national survey identified 10 CTE parameters for evaluating disease activity and predicting PLR. Logistic regression models were used to assess predictive performance in a validation cohort.

Results

Ten CTE parameters related to lesion characterization-includi

SUBMITTER: Yao R 

PROVIDER: S-EPMC12553649 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature