Quality of life following total neoadjuvant therapy for rectal cancer.

ABSTRACT:

Purpose

This study aimed to assess the health-related quality of life (HRQoL) in patients with locally advanced rectal cancer (LARC) undergoing total neoadjuvant therapy (TNT), comparing outcomes with the German general population and colorectal cancer (CRC) patients treated with curative intent.

Methods

In a multicenter, cross-sectional study within the "TNTox" study framework (DRKS 00033000), EORTC QLQ-C30 and QLQ-CR29 questionnaires were distributed to LARC patients who had completed TNT. Mean reference values were compared descriptively, and further exploratory comparisons based on clinical features were performed.

Results

The study included responses from 72 patients. Compared to the German general population, a reduction in mean HRQoL across most domains was obs

SUBMITTER: Wurschi GW 

PROVIDER: S-EPMC12553667 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature