Lipid, lipid-lowering drugs, and bleedings: A Mendelian randomization and retrospective study.

ABSTRACT: Objective: Emerging evidence suggests a potential link between cholesterol metabolism and bleeding. We aimed to examine the causal effect of low-density lipoprotein cholesterol (LDL-C) or lipid-lowering drugs on bleeding outcomes. Methods: Two-sample Mendelian randomization (MR) analyses and two types of drug target MR were conducted to evaluate the associations of LDL-C levels with risks for three bleeding outcomes including intracerebral hemorrhage (ICH), gastrointestinal bleeding (GIBleeding), and hemorrhage from respiratory passages (HRP). Furthermore, the association between LDL-C and bleeding outcomes was re-evaluated in a retrospective cohort study involving patients with coronary artery disease (CAD). Results: MR analyses suggest that LDL-C levels are not assoc

SUBMITTER: Guo S 

PROVIDER: S-EPMC12553848 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature