Causality between aging and interstitial lung disease: A bidirectional two-sample Mendelian randomization study.

ABSTRACT: ObjectiveAging has been shown to be associated with adverse health outcomes in patients with interstitial lung disease. However, the causal relationship between them is not fully understood. In this study, two-sample Mendelian randomization was applied to analyze the causal relationship between aging phenotypes (facial aging and telomere length) and interstitial lung disease risk.MethodsData on single nucleotide polymorphisms were extracted from the pooled dataset of genome-wide association studies. Single nucleotide polymorphisms were used as instrumental variables. The causal association between aging phenotypes and interstitial lung disease risk was evaluated using inverse variance weighting, Bayesian weighted Mendelian randomization, Mendelian randomization-robust adjusted profile scor

SUBMITTER: Luo W 

PROVIDER: S-EPMC12553857 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature