Anatomy-Based Multivariate Model Predicts Boost Coverage Robustness of Dose-Escalated Simultaneous Integrated Boost Radiotherapy in Early Breast Cancer.

ABSTRACT: PurposeThis study assessed dosimetric effects of setup errors on boost target volume (PTVboost) coverage using simultaneous integrated boost (SIB) in early-stage left-sided breast cancer.Methods35 patients who received whole-breast radiotherapy (40.0 Gy/15 Fr) combined with a SIB to the tumor bed (48.0 Gy/15 Fr) were retrospectively analyzed. Translational-rotational coupled errors (1.0°rotation paired with 1.0 mm translation, 2.0° with 2.0 mm, 3.0° with 3.0 mm) were simulated about all axes. The D95 (dose to 95% of the PTVboost) and V95 (volume covered by 95% of the prescribed dose) were assessed through multivariate analysis to explore the relationship between PTVboost coverage and various anatomy factors, including the volume of the PTVboost (V_boost), the distance from the PTVboost cen

SUBMITTER: Wang M 

PROVIDER: S-EPMC12553883 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature