Diagnostic and therapeutic challenges in hyaline-vascular idiopathic multicentric Castleman disease: A case report.

ABSTRACT: The diagnosis of idiopathic multicentric Castleman disease typically requires serum interleukin-6 testing-often inaccessible in resource-limited settings. A female patient in her early 40s presented with 6-month progressive generalized pruritus, low-grade fever, fatigue, and painless multiregional lymphadenopathy. Laboratory studies showed systemic inflammation, computed tomography/ultrasound-confirmed bilateral axillary lymphadenopathy, splenomegaly, and serositis. Lymph node biopsy revealed hyaline-vascular features: atrophic germinal centers with a "lollipop-like" vasculature and "onion skin-like" lymphocyte proliferation. Interleukin-6 testing was unavailable. CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy (nine cycles) combined with thalidomide (100 mg/

SUBMITTER: Lu C 

PROVIDER: S-EPMC12553953 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature