Reliability of Neuroimaging and Neurophysiological Tremor Features in Parkinson's Disease.

ABSTRACT:

Background

Tremor is one of the cardinal motor symptoms of Parkinson's disease (PD). Its severity can be quantified with clinical rating scales and neurophysiology. The pathophysiology of PD tremor involves activity in the cerebello-thalamo-cortical circuit (CTC), which can be quantified with concurrent accelerometry-functional magnetic resonance imaging (fMRI). This opens possibilities for fMRI-informed precision medicine, but it remains unclear if tremor-related fMRI activity is a reliable biomarker at the individual level.

Objectives

To assess the test-retest reliability of three PD tremor outcome measures: clinical rating scales, accelerometry, and combined accelerometry-fMRI.

Methods

We studied 26 tremor-dominant PD patients OFF medication on two separate days (2

SUBMITTER: Angelini L 

PROVIDER: S-EPMC12553995 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature