Brain Networks Route Neurodegeneration Patterns in Patients with Progressive Supranuclear Palsy.

ABSTRACT:

Background

Progressive supranuclear palsy (PSP) is a neurodegenerative disease driven by 4-repeat τ pathology, which is thought to propagate across interconnected neurons.

Objectives

We hypothesized that interconnected brain regions exhibit correlated atrophy, and that atrophy propagates network-like from fast-declining epicenters to connected regions in PSP.

Methods

We combined resting-state functional magnetic resonance imaging (fMRI) connectomics with two independent 12-month longitudinal structural magnetic resonance imaging (MRI) datasets of PSP-Richardson syndrome (PSP-RS) patients (n_discovery/n_validation = 114/90). MRI-based gray matter volumes were assessed for 246 regions of the Brainnetome atlas and converted to w-scores indicating loca

SUBMITTER: Palleis C 

PROVIDER: S-EPMC12553996 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature