Poultry-associated nitrofurantoin-resistant and pre-resistant <i>Escherichia coli</i> clones are found in multiple countries and one-health compartments.

ABSTRACT: Escherichia coli is the most common cause of urinary tract infection (UTI) in humans. The nitrofuran-class antibacterial drug nitrofurantoin is a frequent UTI therapy, with resistance rarely observed. Here we show that nitrofurantoin resistant (NFT-R) E. coli are sometimes excreted by dogs fed a raw meat diet in the city of Bristol, United Kingdom, and that NFT-R and pre-resistant (one mutation away from NFT-R) E. coli can be found contaminating chicken meat sold for human consumption and chicken-based raw dog food in the same city. Using whole genome sequencing, we identified multiple NFT-R or pre-resistant E. coli clones spanning several phylogroups. These clones were dominated by isolates from poultry farms and poultry meat in Europe, Canada, the United State

SUBMITTER: Sealey JE 

PROVIDER: S-EPMC12554031 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature