Neutrophils are key modulators of sex differences in LPS-induced shock in mice.

ABSTRACT: Lipopolysaccharide (LPS) exposure in mice induces robust morbidity and mortality, and is widely used as a model for sepsis. However, the role of biological sex in modulating immune responses during LPS-induced sepsis remains incompletely understood. In this study, we investigated how sex influences immune responses following LPS challenge in mice. Using age-matched mice, we found that during primary LPS challenge, females exhibited significantly higher mortality than males. This difference correlated with greater production of proinflammatory cytokines in females. Further analysis revealed that female myeloid cells expressed higher levels of Toll-like receptor 4, and displayed enhanced activation of NF-κB and MAPK signaling. Additionally, compared with males, female macrophages expressed s

SUBMITTER: Sarkar P 

PROVIDER: S-EPMC12554040 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature