Pre-admission fine particulate matter exposure is associated with invasive pulmonary aspergillosis in patients with severe pneumonia, results from two multicenter cohort studies.

ABSTRACT:

Background

Aspergillus, the causative pathogen of invasive pulmonary aspergillosis (IPA)-a highly lethal infectious disease-produces spores with diameters that fall within the fine particulate matter (PM_2.5) range and are frequently detected in ambient PM_2.5 samples. In this study, we investigated whether pre-admission exposure to PM_2.5 is associated with an increased risk of IPA in patients with severe pneumonia.

Methods

Daily PM_2.5 levels for the six months before admission were obtained from a multicenter retrospective cohort and a multicenter prospective cohort. Multivariable logistic regression was used to assess whether pre-admission PM_2.5 exposure is an independent risk factor of IPA in both cohorts. Pooled concen

SUBMITTER: Zhou H 

PROVIDER: S-EPMC12554048 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature