Apparent diffusion coefficient as a quantitative biomarker for prostate cancer treatment response on a 1.5 Tesla magnetic resonance-linear accelerator: Impact of image registration and acquisition type.

ABSTRACT:

Background and purpose

Diffusion-weighted magnetic resonance imaging (DW-MRI) is a quantitative biomarker for cancer detection and treatment monitoring. On magnetic resonance-linear accelerator (MR-Linac) systems, diffusion-weighted echo planar imaging (DW-EPI) suffers from geometric distortion, reducing the repeatability of apparent diffusion coefficient (ADC) measurements. This study evaluated the effect of low-distortion split acquisition of fast spin-echo signal (SPLICE) sequences, and of image registration on the repeatability coefficient (RC) of ADC.

Materials and methods

ADC bias, repeatability, signal-to-noise ratio (SNR) and geometric fidelity were measured in a diffusion phantom using three DW-EPI and two DW-SPLICE protocols. ADC short-term and long-term RCs were m

SUBMITTER: Nair PP 

PROVIDER: S-EPMC12554063 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature