Trajectories of jugular bulb venous oxygen saturation after cardiac arrest are associated with distinct patterns of cerebral pathophysiology.

ABSTRACT:

Purpose

Jugular bulb venous oxygen saturation (SjvO₂) reflects the balance between cerebral oxygen supply and consumption. Clinically distinct phenotypes of hypoxic ischemic brain injury (HIBI) may have different trajectories of SjvO₂ over time. We aimed to identify trajectories of SjvO₂ over time and explore the relationship between SjvO₂ and potential physiological confounders.

Methods

We conducted a single center retrospective study including comatose survivors of cardiac arrest who underwent SjvO₂ monitoring. We used group-based trajectory modeling to identify distinct trajectories of SjvO₂. We assessed the association between trajectory group and time-varying covariates, mean arterial pressure (MAP) and t

SUBMITTER: Faiver L 

PROVIDER: S-EPMC12554073 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature