Sepsis in the absence of fever: Determining the criteria for and feasibility of future therapeutic temperature management trials.

ABSTRACT:

Objective

The purpose of this study is to examine the occurrence, characteristics, and outcomes of intensive care unit (ICU) patients with sepsis and the absence of fever.

Design

Multicentre, retrospective cohort study.

Setting

Twelve ICUs in Queensland, Australia.

Participants

Adults (≥18 years) admitted to the ICU with sepsis between 1 January 2015 and 31 December 2021 were eligible for inclusion. Patients admitted with seizures, traumatic brain injury, postcardiac arrest, end-of-life care, and elective surgery were excluded, as were readmissions.

Main outcome measures

The primary outcome was fever deficit (defined as degree-hours under 38.3°C) during the first 72 h of ICU admission, and all-cause 30-day mortality was the key secondary outcome.

Resu

SUBMITTER: White KC 

PROVIDER: S-EPMC12554110 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature