Oral anticoagulant reversal and mortality in trauma patients: a multicentre propensity score-matched cohort study.

ABSTRACT:

Background

Oral anticoagulant (OAC) therapy increases bleeding risk but its impact on trauma outcomes and the benefit of reversal remains uncertain. This study aimed to evaluate 1/the effect of preinjury OAC therapy on trauma mortality and 2/the protective role of OAC reversal and its associated thrombotic risk.

Methods

We conducted an observational study using a prospective multicenter trauma registry between January 2012 and December 2023. OAC-treated patients were matched with non-OAC-treated patients using a propensity score. Univariable and multivariable logistic regressions assessed associations between OAC therapy and day 1 and day 7 mortality. The effect of guideline-concordant OAC reversal was evaluated. Thrombotic complications were recorded.

Findings

Of the

SUBMITTER: Lang E 

PROVIDER: S-EPMC12554126 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature