Altered NRF2 signalling in systemic redox imbalance: Insights from non-communicable diseases.

ABSTRACT: The balanced activity of the cytoprotective transcription factor NRF2 is central for maintaining redox, metabolic-energetics, and proteome homeostasis, as well as for regulating inflammatory responses, among other functions. Activated NRF2 regulates the expression of hundreds of genes containing antioxidant response elements (AREs) or electrophile response elements (EpRE) in their regulatory regions, often promoting cytoprotection under stress conditions and contributing to defence against various pathologies and non-communicable diseases (NCDs). The products of increased NRF2 activity, detected systemically, may originate from either the white blood cells, the cells of the vasculature or tissue-derived products that could be secreted into biological fluids. Therefore, assessing basal and

SUBMITTER: Jakubowska M 

PROVIDER: S-EPMC12554130 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature