Biomimetic membrane-coating zinc sulfide nanoparticles for anti-inflammatory combined neuroprotective therapy for spinal cord injury.

ABSTRACT: Spinal cord regeneration remains challenging due to complex inflammatory microenvironments, imbalances in metal ions, and obstacles to neuronal regeneration following spinal cord injury (SCI). Herein, microglial cell membranes coated with zinc sulfide nanoparticles modified with albumin (ZnS@BSA@MM) were designed as an anti-inflammatory combined neuroprotective therapy for SCI. ZnS@BSA@MM NPs were constructed via albumin modification and membrane extrusion and exhibited ROS-scavenging abilities comparable to those of natural products and slow H₂S release under acidic conditions. In vitro and in vivo experiments demonstrated the outstanding therapeutic effects of the ZnS@BSA@MM. In detail, the released H₂S and Zn²⁺ not only inhibit microglial a

SUBMITTER: Qin Q 

PROVIDER: S-EPMC12554133 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature