Colchicine and cardiovascular outcomes in MINOCA: A retrospective cohort study.

ABSTRACT:

Background

MINOCA accounts for 5 %-15 % of myocardial infarctions and is defined by <50 % coronary stenosis without an alternative diagnosis, with heterogeneous mechanisms that complicate care. Given the role of inflammation and microvascular dysfunction, we evaluated whether colchicine improves outcomes.

Methods

We conducted a retrospective cohort study using TriNetX, a federated health research network of 134 million patients from 102 healthcare organizations. Adults (≥18 years) with a primary diagnosis of acute myocardial infarction (AMI) and no revascularization after cardiac catheterization and without alternative diagnosis of elevated troponin were classified as MINOCA according to AHA criteria. Patients with MINOCA on colchicine (≥1 year of use for any indication) wer

SUBMITTER: Oro P 

PROVIDER: S-EPMC12554186 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature