Intranasal delivery of LB244-loaded M2 microglia membrane nanoparticles for targeted treatment of neuroinflammation after I/R brain injury.

ABSTRACT: Ischemic stroke following revascularization therapy inevitably leads to varying degrees of ischemia/reperfusion (I/R) injury. The complexity of post-I/R inflammatory processes have hindered the development of effective strategy to improve functional recovery in stroke patients. Extensive evidence has confirmed that activation of the STING pathway and microglial pyroptosis exacerbates neuroinflammatory responses and neuronal damage in cerebral I/R injury. LB244, a potent STING inhibitor, shows therapeutic promise but suffers from poor solubility and bioavailability. Here, we developed LB244@M2 nanoparticles by encapsulating LB244 in M2 microglia membrane vesicles. Intranasal administration of LB244@M2 enabled direct nose-to-brain delivery, achieving 1.7-fold higher brain accumulation than i

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12554189 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature