Association of physical activity and sedentary behavior with stages of cardiovascular-kidney-metabolic syndrome among U.S. adults: NHANES 2007-2020.

ABSTRACT:

Background

Cardiovascular-kidney-metabolic (CKM) syndrome, newly defined by the American Heart Association, integrates metabolic risk factors, chronic kidney disease, and cardiovascular dysfunction. Although clinically important, evidence-based prevention strategies remain limited. This study examined associations of moderate-to-vigorous physical activity (MVPA) and sedentary behavior (SB) with CKM stage in a representative U.S. adult sample.

Methods

We used survey-weighted multinomial logistic regression and restricted cubic splines (RCS). MVPA was classified as 0, 1-149, and ≥ 150 min/week; SB as <5, 5-8, and ≥ 8 h/day; CKM was staged 0-4 (stage 0 as reference). Predefined subgroups were age (20-59 vs 60-79 years), sex (female vs male) and PIR (high >3.49; medium >1.49-<3.

SUBMITTER: Pang S 

PROVIDER: S-EPMC12554204 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature