Targeted biomimetic fusogenic liposome enhances tumor accumulation, penetration, and therapeutic efficacy of siRNA therapeutics.

ABSTRACT: Blocking the CD47-SIRPα signaling pathway to promote macrophage phagocytosis represents a promising strategy for cancer therapy. RNA interference offers a safe and efficient means to disrupt this pathway, highlighting the importance of developing effective siRNA delivery systems to improve antitumor efficacy. In this study, we developed a biomimetic and fusogenic liposome capable of deep tumor penetration and selective tumor cell targeting for the coordinated cytosolic delivery of CD47 and PLK1-targeting siRNAs. CD47 siRNA downregulated CD47 protein expression, suppressing the "don't eat me" signal, while PLK1 siRNA induced tumor cell apoptosis and enhanced the "eat-me" signal by facilitating the translocation of calreticulin to the cell surface. This biomimetic platform enabled efficient

SUBMITTER: Zhao X 

PROVIDER: S-EPMC12554214 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature