Dual-function hemoglobin-encapsulating ZIF-8 nanoparticles: Oxygen transport capability and carbonic anhydrase-like activity.

ABSTRACT: Hemoglobin-based oxygen carriers (HBOCs) have emerged as a promising alternative to red blood cell (RBC) transfusions, addressing key limitations such as cold storage requirements, restricted availability of universal donor blood, and the need for cross-matching, which collectively hinder their immediate use in emergency settings. Despite their potential, existing HBOCs primarily focus on oxygen delivery while overlooking a crucial physiological function of native RBCs: carbon dioxide (CO₂) transport, which is essential not only for gas exchange but also for acid-base homeostasis. In this study, we explore the potential of our previously developed hemoglobin (Hb)-loaded zeolitic imidazole framework-8 nanoparticles (Hb@ZIF-8 NPs) as a dual-function RBC substitute capable of both

SUBMITTER: Pablo-Sainz-Ezquerra AM 

PROVIDER: S-EPMC12554216 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature