Selenium-functionalized hyaluronic acid dissolvable microneedle patch synergistic herbal shikonin-loaded tetrahedral framework nucleic acids for psoriasis therapy.

ABSTRACT: Psoriasis is a complex, chronic inflammatory skin disease for which current therapies are limited by systemic toxicity, rapid relapse, and incomplete resolution. Despite advances in microneedle (MN)-assisted transdermal drug delivery, conventional systems often suffer from suboptimal pharmacokinetics and limited therapeutic versatility. Here, we engineered a dissolvable MN patch composed of selenium-functionalized hyaluronic acid (SeHA) integrated with shikonin-loaded tetrahedral framework nucleic acids (SFN) to enable sustained drug release while modulating the reactive oxygen species (ROS)-rich psoriatic microenvironment. The SeHA-SFN MNs exhibited robust mechanical properties, permitting efficient penetration of hyperkeratotic epidermis, followed by rapid dissolution and targeted SFN de

SUBMITTER: Zhuo M 

PROVIDER: S-EPMC12554224 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature