Novel variants in ARID1B, SPSB1, and RAET1-AS shape genetic susceptibility and protection in systemic lupus erythematosus and lupus nephritis.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by immune dysregulation affecting multiple organs, most notably lupus nephritis (LN). Genetic susceptibility significantly contributes to disease severity and prognosis. However, genomic studies specific to Taiwanese SLE patients, particularly those focusing on LN, remain limited. This study aimed to identify genetic variants associated with SLE and LN in a Taiwanese cohort.

Methods

Genome-wide association studies (GWAS) were performed on 276 Taiwanese SLE patients compared with 3393 patients with other rheumatic diseases. Single-nucleotide polymorphism (SNP) genotyping was conducted using the Taiwan Precision Medicine Array, with analyses adjusted for age, sex, and population structure. Fu

SUBMITTER: Chen HY 

PROVIDER: S-EPMC12554230 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature