Full-length transcriptome analysis of papillary thyroid carcinoma reveals correlation between LAMB3 expression and clinical features.

ABSTRACT:

Background

Thyroid carcinoma is the most common malignant endocrine tumour, and its prevalence has been on the rise in recent years. However, mechanisms underlying the metastasis of thyroid carcinoma and candidate biomarkers remain elusive. In this study, we screened genes involved in the virulence and metastasis of papillary thyroid carcinoma (PTC).

Methods

Oxford Nanopore Technology full-length transcriptome sequencing and bioinformatic analyses were performed to analyse differentially expressed genes (DEGs) in PTC. We collected 15 cancerous and paracancerous tissue pairs from patients with PTC for RNA sequencing. The significance thresholds for DEGs were |log2(fold change)| ≥ 1 and false discovery rate (FDR) < 0.01. Gene Ontology and Kyoto Encyclopaedia Gene and Genome pa

SUBMITTER: Lyu S 

PROVIDER: S-EPMC12554243 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature