Association of Long-Term Body Mass Index Variability With the Development of Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction Across Patterns of Weight Change.

ABSTRACT:

Background

Body mass index (BMI) variability is a risk factor for various adverse cardiovascular outcomes. However, the specific associations between BMI variability and the risk of developing heart failure with preserved ejection fraction (HFpEF) versus heart failure with reduced ejection fraction (HFrEF), particularly across multiple weight change trends, remain unexplored.

Methods

This retrospective cohort study analyzed electronic health records from a sample of patients with overweight or obesity. BMI variability was assessed over a 5-year period using average successive variability, with patients categorized into 3 groups: weight loss, stable weight, and weight gain. We subsequently followed 50 812 eligible patients to monitor the incidence of HFpEF and HFrEF. Cox regr

SUBMITTER: Yu Z 

PROVIDER: S-EPMC12554408 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature